Template:Infobox calcium Calcium (pronounced /ˈkælsiəm/, Template:Respell) is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft gray alkaline earth metal, and is the fifth most abundant element by mass in the Earth's crust. Calcium is also the fifth most abundant dissolved ion in seawater by both molarity and mass, after sodium, chloride, magnesium, and sulfate.
Calcium is essential for living organisms, particularly in cell physiology, where movement of the calcium ion Ca2+ into and out of the cytoplasm functions as a signal for many cellular processes. As a major material used in mineralization of bones and shells, calcium is the most abundant metal by mass in many animals.
Chemically calcium is reactive and soft for a metal (though harder than lead, it can be cut with a knife with difficulty). It is a silvery metallic element that must be extracted by electrolysis from a fused salt like calcium chloride. Once produced, it rapidly forms a gray-white oxide and nitride coating when exposed to air. It is somewhat difficult to ignite, unlike magnesium, but when lit, the metal burns in air with a brilliant high-intensity red light. Calcium metal reacts with water, evolving hydrogen gas at a rate rapid enough to be noticeable, but not fast enough at room temperature to generate much heat. In powdered form, however, the reaction with water is extremely rapid, as the increased surface area of the powder accelerates the reaction with the water. Part of the slowness of the calcium-water reaction results from the metal being partly protected by insoluble white calcium hydroxide. In water solutions of acids where the salt is water soluble, calcium reacts vigorously.
Calcium, with a specific mass of 1.55 g/cm3, is the lightest of the alkali earth metals; magnesium (1.74) and beryllium (1.84) are heavier although they are lighter in atomic mass. From strontium on, the alkali earth metals get heavier along with the atomic mass.
Calcium has a higher electrical resistivity than copper or aluminium. Yet, weight for weight, allowing for its much lower density, it is a rather better conductor than either. However, its use in terrestrial applications is usually limited by its high reactivity with air.
Calcium salts are colorless from any contribution of the calcium, and ionic solutions of calcium (Ca2+) are colorless as well. Many calcium salts are not soluble in water. When in solution, the calcium ion to the human taste varies remarkably, being reported as mildly salty, sour, "mineral like" or even "soothing." It is apparent that many animals can taste, or develop a taste, for calcium, and use this sense to detect the mineral in salt licks or other sources. In human nutrition, soluble calcium salts may be added to tart juices without much effect to the average palate.
Calcium is the fifth most abundant element by mass in the human body, where it is a common cellular ionic messenger with many functions, and serves also as a structural element in bone. It is the relatively high atomic-numbered calcium in the skeleton which causes bone to be radio-opaque. Of the human body's solid components after drying (as for example, after cremation), about a third of the total mass is the approximately one kilogram of calcium which composes the average skeleton (the remainder being mostly phosphorus and oxygen).
H and K linesEdit
Visible spectra of many stars, including the Sun, exhibit strong absorption lines of singly-ionized calcium. Prominent among these are the H-line at 3968.5 Å and the K line at 3933.7 Å of singly-ionized calcium, or Ca II. For the Sun and stars with low temperatures, the prominence of the H and K lines can be an indication of strong magnetic activity in the chromosphere. Measurement of periodic variations of these active regions can also be used to deduce the rotation periods of these stars.
Calcium hydroxide (slaked lime) is used in many chemical refinery processes and is made by heating limestone at high temperature (above 825 °C) and then carefully adding water to it. When lime is mixed with sand, it hardens into a mortar and is turned into plaster by carbon dioxide uptake. Mixed with other compounds, lime forms an important part of Portland cement.
Calcium carbonate (CaCO3) is one of the common compounds of calcium. It is heated to form quicklime (CaO), which is then added to water (H2O). This forms another material known as slaked lime (Ca(OH)2), which is an inexpensive base material used throughout the chemical industry. Chalk, marble, and limestone are all forms of calcium carbonate.
When water percolates through limestone or other soluble carbonate rocks, it partially dissolves the rock and causes cave formation and characteristic stalactites and stalagmites and also forms hard water. Other important calcium compounds are calcium nitrate, calcium sulfide, calcium chloride, calcium carbide, calcium cyanamide and calcium hypochlorite.
- Main article: Isotopes of calcium
Calcium has four stable isotopes (40Ca and 42Ca through 44Ca), plus two more isotopes (46Ca and 48Ca) that have such long half-lives that for all practical purposes they can be considered stable. The 20% range in relative mass among naturally-occurring calcium isotopes is greater than for any element except hydrogen and helium. Calcium also has a cosmogenic isotope, radioactive 41Ca, which has a half-life of 103,000 years. Unlike cosmogenic isotopes that are produced in the atmosphere, 41Ca is produced by neutron activation of 40Ca. Most of its production is in the upper metre or so of the soil column, where the cosmogenic neutron flux is still sufficiently strong. 41Ca has received much attention in stellar studies because it decays to 41K, a critical indicator of solar-system anomalies.
97% of naturally occurring calcium is in the form of 40Ca. 40Ca is one of the daughter products of 40K decay, along with 40Ar. While K-Ar dating has been used extensively in the geological sciences, the prevalence of 40Ca in nature has impeded its use in dating. Techniques using mass spectrometry and a double spike isotope dilution have been used for K-Ca age dating.
The most abundant isotope, 40Ca, has a nucleus of 20 protons and 20 neutrons. This is the heaviest stable isotope of any element which has equal numbers of protons and neutrons. In supernova explosions, calcium is formed from the reaction of carbon with various numbers of alpha particles (helium nuclei), until the most common calcium isotope (containing 10 helium nuclei) has been synthesized.
As with the isotopes of other elements, a variety of processes fractionate, or alter the relative abundance of, calcium isotopes. The best studied of these processes is the mass dependent fractionation of calcium isotopes that accompanies the precipitation of calcium minerals, such as calcite, aragonite and apatite, from solution. Isotopically light calcium is preferentially incorporated into minerals, leaving the solution from which the mineral precipitated enriched in isotopically heavy calcium. At room temperature the magnitude of this fractionation is roughly 0.25‰ (0.025%) per atomic mass unit (AMU). Mass-dependant differences in calcium isotope composition conventionally are expressed the ratio of two isotopes (usually 44Ca/40Ca) in a sample compared to the same ratio in a standard reference material. 44Ca/40Ca varies by about 1% among common earth materials.
Calcium isotope fractionation during mineral formation has led to several applications of calcium isotopes. In particular, the 1997 observation by Skulan and DePaolo that calcium minerals are isotopically lighter than the solutions from which the minerals precipitate is the basis of analogous applications in medicine and in paleooceanography. In animals with skeletons mineralized with calcium the calcium isotopic composition of soft tissues reflects the relative rate of formation and dissolution of skeletal mineral. In humans changes in the calcium isotopic composition of urine have been shown to be related to changes in bone mineral balance. When the rate of bone formation exceeds the rate of bone resorption, soft tissue 44Ca/40Ca rises. Soft tissue 44Ca/40Ca falls when bone resorption exceeds bone formation. Because of this relationship, calcium isotopic measurements of urine or blood may be useful in the early detection of metabolic bone diseases like osteoporosis.
A similar system exists in the ocean, where seawater 44Ca/40Ca tends to rise when the rate of removal of Ca2+ from seawater by mineral precipitation exceeds the input of new calcium into the ocean, and fall when calcium input exceeds mineral precipitation. It follows that rising 44Ca/40Ca corresponds to falling seawater Ca2+ concentration, and falling 44Ca/40Ca corresponds to rising seawater Ca2+ concentration. In 1997 Skulan and DePaolo presented the first evidence of change in seawater 44Ca/40Ca over geologic time, along with a theoretical explanation of these changes. More recent papers have confirmed this observation, demonstrating that seawater Ca2+ concentration is not constant, and that the ocean probably never is in “steady state” with respect to its calcium input and output. This has important climatological implications, as the marine calcium cycle is closely tied to the carbon cycle (see below).
Calcium provides an important link between tectonics, climate and the carbon cycle. In the simplest terms, uplift of mountains exposes Ca-bearing rocks to chemical weathering and releases Ca2+ into surface water. This Ca2+ eventually is transported to the ocean where it reacts with dissolved CO2 to form limestone. Some of this limestone settles to the sea floor where it is incorporated into new rocks. Dissolved CO2, along with carbonate and bicarbonate ions, are referred to as dissolved inorganic carbon (DIC).
The actual reaction is more complicated and involves the bicarbonate ion (HCO3-) that forms when CO2 reacts with water at seawater pH:
- Ca2+ + 2HCO3 → CaCO3 (limestone) + CO2 + H2O
Note that at ocean pH most of the CO2 produced in this reaction is immediately converted back into HCO3-. The reaction results in a net transport of one molecule of CO2 from the ocean/atmosphere into the lithosphere.
The result is that each Ca2+ ion released by chemical weathering ultimately removes one CO2 molecule from the surficial system (atmosphere, ocean, soils and living organisms), storing it in carbonate rocks where it is likely to stay for hundreds of millions of years. The weathering of calcium from rocks thus scrubs CO2 from the ocean and atmosphere, thereby exerting a strong long-term effect on climate. Analogous cycles involving magnesium, and to a much smaller extent strontium and barium, have the same effect.
As the weathering of limestone (CaCO3) liberates equimolar amounts of Ca2+ and CO2, it has no net effect on the CO2 content of the atmosphere and ocean. The weathering of silicate rocks like granite, on the other hand, is a net CO2 sink because it produces abundant Ca2+ very little CO2.
Calcium (Latin word calcis meaning "lime") was known as early as the first century when the Ancient Romans prepared lime as calcium oxide. Literature dating back to 975 AD notes that plaster of paris (calcium sulphate), is useful for setting broken bones. It was not isolated until 1808 in England when Sir Humphry Davy electrolyzed a mixture of lime and mercuric oxide. Davy was trying to isolate calcium; when he heard that Swedish chemist Jöns Jakob Berzelius and Pontin prepared calcium amalgam by electrolyzing lime in mercury, he tried it himself. He worked with electrolysis throughout his life and also discovered/isolated sodium, potassium, magnesium, boron and barium. Calcium metal was not available in large scale until the beginning of the 20th century.
Calcium is not naturally found in its elemental state. Calcium occurs most commonly in sedimentary rocks in the minerals calcite, dolomite and gypsum. It also occurs in igneous and metamorphic rocks chiefly in the silicate minerals: plagioclase, amphiboles, pyroxenes and garnets.
Calcium is used
- as a reducing agent in the extraction of other metals, such as uranium, zirconium, and thorium.
- as a deoxidizer, desulfurizer, or decarbonizer for various ferrous and nonferrous alloys.
- as an alloying agent used in the production of aluminium, beryllium, copper, lead, and magnesium alloys.
- in the making of cements and mortars to be used in construction.
- in the making of cheese, where calcium ions influence the activity of rennin in bringing about the coagulation of milk.
- Calcium carbonate (CaCO3) is used in manufacturing cement and mortar, lime, limestone (usually used in the steel industry) and aids in production in the glass industry. It also has chemical and optical uses as mineral specimens in toothpastes, for example.
- Calcium hydroxide solution (Ca(OH)2) (also known as limewater) is used to detect the presence of carbon dioxide by being bubbled through a solution. It turns cloudy where CO2 is present.
- Calcium arsenate (Ca3(AsO4)2) is used in insecticides.
- Calcium carbide (CaC2) is used to make acetylene gas (for use in acetylene torches for welding) and in the manufacturing of plastics.
- Calcium chloride (CaCl2) is used in ice removal and dust control on dirt roads, in conditioner for concrete, as an additive in canned tomatoes, and to provide body for automobile tires.
- Calcium cyclamate (Ca(C6H11NHSO3)2) was used as a sweetening agent but is no longer permitted for use because of suspected cancer-causing properties.
- Calcium gluconate (Ca(C6H11O7)2) is used as a food additive and in vitamin pills.
- Calcium hypochlorite (Ca(OCl)2) is used as a swimming pool disinfectant, as a bleaching agent, as an ingredient in deodorant, and in algaecide and fungicide.
- Calcium permanganate (Ca(MnO4)2) is used in liquid rocket propellant, textile production, as a water sterilizing agent and in dental procedures.
- Calcium phosphate (Ca3(PO4)2) is used as a supplement for animal feed, fertilizer, in commercial production for dough and yeast products, in the manufacture of glass, and in dental products.
- Calcium phosphide (Ca3P2) is used in fireworks, rodenticide, torpedoes and flares.
- Calcium stearate (Ca(C18H35O2)2) is used in the manufacture of wax crayons, cements, certain kinds of plastics and cosmetics, as a food additive, in the production of water resistant materials and in the production of paints.
- Calcium sulfate (CaSO4·2H2O) is used as common blackboard chalk, as well as, in its hemihydrate form better known as Plaster of Paris.
- Calcium tungstate (CaWO4) is used in luminous paints, fluorescent lights and in X-ray studies.
- Hydroxylapatite (Ca5(PO4)3(OH), but is usually written Ca10(PO4)6(OH)2) makes up seventy percent of bone. Also carbonated-calcium deficient hydroxylapatite is the main mineral of which dental enamel and dentin are comprised.
- Main article: Calcium in biology
Calcium is an important component of a healthy diet and a mineral necessary for life. The National Osteoporosis Foundation says, "Calcium plays an important role in building stronger, denser bones early in life and keeping bones strong and healthy later in life." Approximately ninety-nine percent of the body's calcium is stored in the bones and teeth. The rest of the calcium in the body has other important uses, such as some exocytosis, especially neurotransmitter release, and muscle contraction. In the electrical conduction system of the heart, calcium replaces sodium as the mineral that depolarizes the cell, proliferating the action potential. In cardiac muscle, sodium influx commences an action potential, but during potassium efflux, the cardiac myocyte experiences calcium influx, prolonging the action potential and creating a plateau phase of dynamic equilibrium. Long-term calcium deficiency can lead to rickets and poor blood clotting and in case of a menopausal woman, it can lead to osteoporosis, in which the bone deteriorates and there is an increased risk of fractures. While a lifelong deficit can affect bone and tooth formation, over-retention can cause hypercalcemia (elevated levels of calcium in the blood), impaired kidney function and decreased absorption of other minerals. High calcium intakes or high calcium absorption were previously thought to contribute to the development of kidney stones. However, a high calcium intake has been associated with a lower risk for kidney stones in more recent research. Vitamin D is needed to absorb calcium.
Dairy products, such as milk and cheese, are a well-known source of calcium. Some individuals are allergic to dairy products and even more people, particularly those of non Indo-European descent, are lactose-intolerant, leaving them unable to consume non-fermented dairy products in quantities larger than about half a liter per serving. Others, such as vegans, avoid dairy products for ethical and health reasons. Fortunately, many good sources of calcium exist. These include seaweeds such as kelp, wakame and hijiki; nuts and seeds (like almonds and sesame); blackstrap molasses; beans; oranges; figs; quinoa; amaranth; collard greens; okra; rutabaga; broccoli; dandelion leaves; kale; and fortified products such as orange juice and soy milk. Research has found an association between diets high in animal protein and increased urinary calcium loss from the bones. A diet high in fruit, vegetables and cereals was demonstrated to result in greater femoral bone mineral density in older men, in comparison to a range of other diets. Diets high in candy were found to result in lower bone density in both men and women.. An overlooked source of calcium is eggshell, which can be ground into a powder and mixed into food or a glass of water. Cultivated vegetables generally have less calcium than wild plants.
The calcium content of most foods can be found in the USDA National Nutrient Database.
Dietary calcium supplementsEdit
Calcium supplements are used to prevent and to treat calcium deficiencies. Most experts recommend that supplements be taken with food and that no more than 600 mg should be taken at a time because the percent of calcium absorbed decreases as the amount of calcium in the supplement increases. It is recommended to spread doses throughout the day. Recommended daily calcium intake for adults ranges from 1000 to 1500 mg. It is recommended to take supplements with food to aid in absorption.
Vitamin D is added to some calcium supplements. Proper vitamin D status is important because vitamin D is converted to a hormone in the body which then induces the synthesis of intestinal proteins responsible for calcium absorption.
- The absorption of calcium from most food and commonly-used dietary supplements is very similar. This is contrary to what many calcium supplement manufacturers claim in their promotional materials.
- Milk is an excellent source of dietary calcium because it has a high concentration of calcium and the calcium in milk is excellently absorbed.
- Calcium carbonate is the most common and least expensive calcium supplement. It should be taken with food. It depends on low pH levels for proper absorption in the intestine. Some studies suggests that the absorption of calcium from calcium carbonate is similar to the absorption of calcium from milk. While most people digest calcium carbonate very well, some might develop gastrointestinal discomfort or gas. Taking magnesium with it can help to avoid constipation. Calcium carbonate is 40% elemental calcium. 1000 mg will provide 400 mg of calcium. However, supplement labels will usually indicate how much calcium is present in each serving, not how much calcium carbonate is present.
- Antacids, such as Tums, frequently contain calcium carbonate, and are a very commonly-used, inexpensive calcium supplement.
- Coral Calcium is a salt of calcium derived from fossilized coral reefs. Coral calcium is composed of calcium carbonate and trace minerals.
- Calcium citrate can be taken without food and is the supplement of choice for individuals with achlorhydria or who are taking histamine-2 blockers or proton-pump inhibitors. It is more easily digested and absorbed than calcium carbonate if taken on empty stomach and less likely to cause constipation and gas than calcium carbonate. It also has a lower risk of contributing to the formation of kidney stones. Calcium citrate is about 21% elemental calcium. 1000 mg will provide 210 mg of calcium. It is more expensive than calcium carbonate and more of it must be taken to get the same amount of calcium.
- Calcium phosphate costs more than calcium carbonate, but less than calcium citrate. It is easily absorbed and is less likely to cause constipation and gas than either.
- Calcium lactate has similar absorption as calcium carbonate, but is more expensive. Calcium lactate and calcium gluconate are less concentrated forms of calcium and are not practical oral supplements.
- Calcium chelates are synthetic calcium compounds, with calcium bound to an organic molecule, such as malate, aspartate, or fumarate. These forms of calcium may be better absorbed on an empty stomach. However, in general they are absorbed similarly to calcium carbonate and other common calcium supplements when taken with food. The 'chelate' mimics the action that natural food performs by keeping the calcium soluble in the intestine. Thus, on an empty stomach, in some individuals, chelates might theoretically be absorbed better.
- Microcrystalline hydroxyapatite (MH) is marketed as a calcium supplement, and has in some randomized trials been found to be more effective than calcium carbonate.
- Orange juice with calcium added is a good dietary source for persons who have lactose intolerance.
In July 2006, a report citing research from Fred Hutchinson Cancer Research Center in Seattle, Washington claimed that women in their 50s gained 5 pounds less in a period of 10 years by taking more than 500 mg of calcium supplements than those who did not. However, the doctor in charge of the study, Dr. Alejandro J. Gonzalez also noted it would be "going out on a limb" to suggest calcium supplements as a weight-limiting aid.
Prevention of fractures due to osteoporosisEdit
Such studies often do not test calcium alone, but rather combinations of calcium and vitamin D. Randomized controlled trials found both positive and negative effects. The different results may be explained by doses of calcium and underlying rates of calcium supplementation in the control groups. However, it is clear that increasing the intake of calcium promotes deposition of calcium in the bones, where it is of more benefit in preventing the compression fractures resulting from the osteoporotic thinning of the dendritic web of the bodies of the vertebrae, than it is at preventing the more serious cortical bone fractures which happen at hip and wrist.
Possible cancer preventionEdit
A meta-analysis by the international Cochrane Collaboration of two randomized controlled trials found that calcium "might contribute to a moderate degree to the prevention of adenomatous colonic polyps".
More recent studies were conflicting, and one which was positive for effect (Lappe, et al.) did control for a possible anti-carcinogenic effect of vitamin D, which was found to be an independent positive influence from calcium-alone on cancer risk (see second study below) .
- A randomized controlled trial found that 1000 mg of elemental calcium and 400 IU of vitamin D3 had no effect on colorectal cancer
- A randomized controlled trial found that 1400–1500 mg supplemental calcium and 1100 IU vitamin D3 reduced aggregated cancers with a relative risk of 0.402.
- An observational cohort study found that high calcium and vitamin D intake was associated with "lower risk of developing premenopausal breast cancer."
Hazards and ToxicityEdit
Compared to other metals, the calcium ion and most calcium compounds have low toxicity. This is not surprising given the very high natural abundance of calcium compounds in the environment and in organisms. Calcium poses few, if any, serious environmental problems. Acute calcium poisoning is rare, and difficult to achieve unless calcium compounds are administered intravenously. For example, the oral LD50 for rats for calcium carbonate and calcium chloride are 6450  and 1400 mg/kg, respectively.
Calcium metal is hazardous because of its sometimes violent reactions with water and acids. Calcium metal is found in some drain cleaners, where it functions to generate heat and calcium hydroxide that saponifies the fats and liquefies the proteins (e.g., hair) that block drains. When swallowed calcium metal has the same effect on the mouth, esophagus and stomach, and can be fatal.
Excessive consumption of calcium carbonate antacids/dietary supplements (such as Tums) over a period of weeks or months can cause milk-alkali syndrome, with symptoms ranging from hypercalcemia to potentially fatal renal failure. What constitutes “excessive” consumption is not well known and probably varies a great deal from person to person. Persons who consume more than 10 grams/day of CaCO3 (=4 g Ca) are at risk of developing milk-alkali syndrome,  but the condition has been reported in at least one person consuming only 2.5 grams/day of CaCO3 (=1 g Ca), an amount usually considered moderate and safe. 
- ↑ Dickson, A. G. and Goyet, C. (1994). "5". Handbook of method for the analysis of the various parameters of the carbon dioxide system in sea water, version 2, ORNL/CDIAC-74, http://cdiac.esd.ornl.gov/ftp/cdiac74/chapter5.pdf.
- ↑ Pauling, Linus (1970). General Chemistry, Dover Publications. p. 627. ISBN 0716701499.
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- ↑ Staff (1995). "H-K Project". Mount Wilson Observatory. Retrieved on 2006-08-10.
- ↑ Russell, WA; Papanastassiou, DA; Tombrello, TA (1978). "Ca isotope fractionation on the earth and other solar system materials". Geochim Cosmochim Acta 42: 1075–90. doi:10.1016/0016-7037(78)90105-9.
- ↑ Skulan, J; DePaolo, DJ (1999). "Calcium isotope fractionation between soft and mineralized tissues as a monitor of calcium use in vertebrates". Proc Natl Acad Sci USA 96 (24): 13709–13. doi:10.1073/pnas.96.24.13709. PMID 10570137.
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- ↑ Fantle, M; DePaolo, D (2007). "Ca isotopes in carbonate sediment and pore fluid from ODP Site 807A: The Ca2+(aq)–calcite equilibrium fractionation factor and calcite recrystallization rates in Pleistocene sediments". Geochim Cosmochim Acta 71: 2524–2546. doi:10.1016/j.gca.2007.03.006.
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- ↑ Zeebe (2006). "Marine carbonate chemistry". National Council for Science and the Environment. Retrieved on 2010-03-13.
- ↑ Berner, Robert (2003). "The long-term carbon cycle, fossil fuels and atmospheric composition". Nature 426: 323-326.
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- ↑ 14.0 14.1 "Dietary Supplement Fact Sheet: Calcium".
- ↑ "Osteoporosis Prevention - Calcium Recommendations".
- ↑ Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine (1997). Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and fluoride. Washington DC: The National Academies Press. ISBN 0309064031.
- ↑ Curhan, Gc; Willett, Wc; Rimm, Eb; Stampfer, Mj (1993). "A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones.". The New England journal of medicine 328 (12): 833–8. doi:10.1056/NEJM199303253281203. PMID 8441427.
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- ↑ Tucker, KL; Chen, H; Hannan, MT; Cupples, LA; Wilson, PW; Felson, D; Kiel, DP (2002). "Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study.". The American journal of clinical nutrition 76 (1): 245–52. PMID 12081842.
- ↑ Schaafsma, Anne and Beelen, Gerard M (1999). "Eggshell powder, a comparable or better source of calcium than purified calcium carbonate: piglet studies" (abstract). Journal of the Science of Food and Agriculture 79 (12): 1596–1600. doi:10.1002/(SICI)1097-0010(199909)79:12<1596::AID-JSFA406>3.0.CO;2-A, http://www3.interscience.wiley.com/cgi-bin/abstract/63003036/ABSTRACT.
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- ↑ "USDA National Nutrient Database".
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- ↑ Remington, Joseph (2005). Remington: The Science and Practice of Pharmacy, Lippincott Williams & Wilkins. pp. 1338. ISBN 0781746736.
- ↑ Zhao, Y; Martin, BR; Weaver, CM (2005). "Calcium bioavailability of calcium carbonate fortified soy milk is equivalent to cow's milk in young women". J. Nutr. 135 (10): 2379. PMID 16177199, http://jn.nutrition.org/cgi/content/full/135/10/2379.
- ↑ Martini, Ligia and Wood, Richard J (2002). "Relative bioavailability of calcium-rich dietary sources in the elderly". American Journal of Clinical Nutrition 76 (6): 1345–1350. PMID 12450902, http://www.ajcn.org/cgi/content/abstract/76/6/1345.
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- ↑ Martin, Berdine R.; Weaver, CM; Heaney, RP; Packard, PT; Smith, DL (2002). "Calcium Absorption from Three Salts and CaSO4-Fortified Bread in Premenopausal Women". Journal of Agricultural and Food Chemistry 50 (13): 3874. doi:10.1021/jf020065g. PMID 12059174.
- ↑ Weaver, Connie M.; Martin, BR; Costa, NM; Saleeb, FZ; Huth, PJ (2002). "Absorption of Calcium Fumarate Salts Is Equivalent to Other Calcium Salts When Measured in the Rat Model". Journal of Agricultural and Food Chemistry 50 (17): 4974. doi:10.1021/jf0200422. PMID 12166992.
- ↑ Harding, Anne. "Calcium May Help With Weight Loss". Retrieved on 2007-07-10.
- ↑ Dawson-Hughes B, Harris SS, Krall EA, Dallal GE (1997). "Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older". N. Engl. J. Med. 337 (10): 670–6. doi:10.1056/NEJM199709043371003. PMID 9278463.
- ↑ 39.0 39.1 Weingarten MA, Zalmanovici A, Yaphe J (2005). "Dietary calcium supplementation for preventing colorectal cancer, adenomatous polyps and calcium metabolisism disorder.". Cochrane database of systematic reviews (Online) (3): CD003548. doi:10.1002/14651858.CD003548.pub3. PMID 16034903.
- ↑ Jackson RD, LaCroix AZ, Gass M (2006). "Calcium plus vitamin D supplementation and the risk of fractures". N. Engl. J. Med. 354 (7): 669–83. doi:10.1056/NEJMoa055218. PMID 16481635.
- ↑ Grant AM, Avenell A, Campbell MK (2005). "Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial". Lancet 365 (9471): 1621–8. doi:10.1016/S0140-6736(05)63013-9. PMID 15885294.
- ↑ Porthouse J, Cockayne S, King C (2005). "Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care". BMJ 330 (7498): 1003. doi:10.1136/bmj.330.7498.1003. PMID 15860827.
- ↑ Prince RL, Devine A, Dhaliwal SS, Dick IM (2006). "Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women". Arch. Intern. Med. 166 (8): 869–75. doi:10.1001/archinte.166.8.869. PMID 16636212.
- ↑ Fletcher RH (2006). "Calcium plus vitamin D did not prevent hip fracture or colorectal cancer in postmenopausal women" (subscription required). ACP J. Club 145 (1): 4–5. PMID 16813354, http://www.acpjc.org/Content/145/1/issue/ACPJC-2006-145-1-004.htm.
- ↑ Baron JA, Beach M, Mandel JS (1999). "Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group". N. Engl. J. Med. 340 (2): 101–7. doi:10.1056/NEJM199901143400204. PMID 9887161.
- ↑ Bonithon-Kopp C, Kronborg O, Giacosa A, Räth U, Faivre J (2000). "Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group". Lancet 356 (9238): 1300–6. doi:10.1016/S0140-6736(00)02813-0. PMID 11073017.
- ↑ Lappe, Jm; Travers-Gustafson, D; Davies, Km; Recker, Rr; Heaney, Rp (2007). "Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial." (Free full text). The American journal of clinical nutrition 85 (6): 1586–91. PMID 17556697, http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=17556697.
- ↑ Wactawski-Wende J, Kotchen JM, Anderson GL (2006). "Calcium plus vitamin D supplementation and the risk of colorectal cancer". N. Engl. J. Med. 354 (7): 684–96. doi:10.1056/NEJMoa055222. PMID 16481636.
- ↑ Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP (2007). "Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial". Am. J. Clin. Nutr. 85 (6): 1586–91. PMID 17556697.
- ↑ Lin J, Manson JE, Lee IM, Cook NR, Buring JE, Zhang SM (2007). "Intakes of calcium and vitamin d and breast cancer risk in women". Arch. Intern. Med. 167 (10): 1050–9. doi:10.1001/archinte.167.10.1050. PMID 17533208.
- ↑ Lewis, R. J. (1996), Sax's Dangerous Properties of Industrial Materials. (9th ed.), New York, NY: Van Nostrand Reinhold, pp. 635
- ↑ ITII. Toxic and Hazardous Industrial Chemicals Safety Manual, Tokyo, Japan: The International Technical Information Institute, 1988, pp. 101
- ↑ Rumack BH. POISINDEX. Information System Micromedex, Inc., Englewood, CO, 2010; CCIS Volume 143. Hall AH and Rumack BH (Eds)
- ↑ Beall DP, Henslee HB, Webb HR, Scofield RH (May 2006). "Milk-alkali syndrome: a historical review and description of the modern version of the syndrome". Am. J. Med. Sci. 331 (5): 233–42. doi:10.1097/00000441-200605000-00001. PMID 16702792, http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00000441-200605000-00001.
- ↑ Picolos MK and Orlander PR (2005). "Calcium carbonate toxicity: The updated milk-alkali syndrome; report of 3 cases and review of the literature". Endocrine Practice 4 (11): 272-80.
- Rebecca J. Donatelle. Health, The Basics. 6th ed. San Francisco: Pearson Education, Inc. 2005.
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